Articles — Recent

episode 9

Förbättrad version av det jag la upp tidigare.

Introduction to quantum mechanical effects and an implementation example of quantum key distribution

Craig Cook

Power consumption is a troublesome design constraint for HPC systems. If current trends continue, future petaflop systems will require 100 megawatts of power to maintain high-performance. To address this problem the power and energy characteristics of high performance systems must be characterised. The main idea of this project is to design a methodology for the optimal selection (minimal number of systems that maximise performance and minimise energy consumption) of a network topology for high performance applications using ultra-low-voltage microprocessors platforms (Intel® AtomTM Processor E3825 - Minnowboard).

Modelo de CV para o português Adapted from the TwentySeconds CV template.

TRABAJO REALIZADO PARA LA MATERIA DE ANÁLISIS Y DISEÑO DE SISTEMAS

Alzheimer’s disease is characterized by death of cholinergic neurons, which secrete the neurotransmitter acetylcholine. This results in a loss of the total amount of acetylcholine circulating in neural networks. Modern drugs target acetylcholinesterase so as to inhibit its function, allowing for increased transmission of acetylcholine in cholinergic synapses. The aim is that an increase in cholinergic activity leads to an increase in cognition. However, these drugs only bind temporarily and have consequential problems that make modern AChE inhibitors of little effect. The main goal of our project is to engineer a snake toxin, fasciculin-II, capable of crossing the blood brain barrier and inhibiting acetylcholinesterase with enough affinity that it increases cholinergic transmission without yielding toxic outcomes. This fasciculin binds to the peripheral acetylcholinesterase found in neuromuscular junctions and causes rapid twitching. Fasciculin-II binds to acetylcholinesterase very tightly with the use of many charged residues and hydrophobic residues and we would like to optimize this interaction so that it may serve a therapeutic purpose in patients of AD.

My 1st blog entry